TPS5091 Background: ENZA is approved to treat men with mCRPC. TALA is a dual-mechanism PARP inhibitor that inhibits PARP1 and PARP2 catalytic activity and traps PARP on DNA, preventing DNA damage repair and causing cell death in BRCA1/2-mutated cells. A combination of TALA with ENZA in DNA damage repair (DDR)+ mCRPC may improve clinical outcomes. Methods: Part 1 (P1) is open label to confirm

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Current use of potent P-gp inhibitors within 7 days prior to Day 1 (Part 1) or randomization (Part 2). Major surgery (as defined by the investigator) within 2 weeks before Day 1 (Part 1) or randomization (Part 2), or palliative localized radiation therapy within 3 weeks before randomization (Part 2).

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Methods: Part 1 (P1) is open label to confirm India vs Sri Lanka 2nd Test Day 3 : SL All out 183, Enforce Follow-on SL Bat Again A combination of TALA with ENZA in mCRPC may improve clinical outcomes in patients with or without DDR-deficient tumors.
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